About hc-10

Summary

This data set contains the raw data files of current injection sweeps from somatic injections of the experimental cells (mouse and rat under standard “control” in vitro recording conditions) that were used to constrain the model cells of the model CA1 neural network published in: Marianne J. Bezaire, Ivan Raikov, Kelly Burk, Dhrumil Vyas, and Ivan Soltesz. Interneuronal mechanisms of hippocampal theta oscillations in full-scale models of the CA1 circuit. Under Review, 2016.

Results from the experiments are described in:

Sang-Hun Lee, Ivan Marchionni, Marianne Bezaire, Csaba Varga, Nathan Danielson, Matthew Lovett-Barron, Attila Losonczy, and Ivan Soltesz. Parvalbumin-positive basket cells differentiate among hippocampal pyramidal cells. Neuron, 82(5):1129–1144, 2014. doi: 10.1016/j.neuron.2014.03.034.

Esther Krook-Magnuson, Lillian Luu, Sang-Hun Lee, Csaba Varga, and Ivan Soltesz. Ivy and neurogliaform interneurons are a major target of µ-opioid receptor modulation. The Journal of Neuroscience, 31(42):14861–14870, 2011. doi: 10.1523/JNEUROSCI.2269-11.2011.

Sang-Hun Lee, Csaba Foldy, and Ivan Soltesz. Distinct endocannabinoid control of GABA release at perisomatic and dendritic synapses in the hippocampus. J. Neurosci., 30:7993–8000, 2010. doi: 10.1523/JNEUROSCI.6238-09.2010.

Format of the data

The data consists of the 37 full current injection sweeps. The files are in a custom format (ATF; AxoClamp text file) but are tab-delimited ASCII text files so they can be read by almost any software application. Information about the format and freely available software to read it (SimTracker) are described in the data description document linked to at the bottom of this page. Total size of the data is about 29 MB (compressed).

How to download the data

Data may be downloaded from:
https://portal.nersc.gov/project/crcns/download/hc-10
A CRCNS.org account is required. See the download link for more instructions.

Getting help using the data.

If you have questions about using the data, post them on the forum for using data sets.

How to cite the data

Publications created through usage of the data should cite the publication given for the data used in the table in the data description document (linked to at bottom of this page) and also cite the data set using the following:

Sang-Hun Lee, Esther Krook-Magnuson, Marianne Bezaire, and Ivan Soltesz (2016); Intracellular, in vitro somatic membrane potential recordings from whole cell patch clamped rodent hippocampal CA1 neurons. CRCNS.org
http://dx.doi.org/10.6080/K00P0WXQ

The above citation uses a Digital Object Identifier (DOI) which is assigned to the data set.  The DOI was created using DataCite (www.datacite.org) and the California Digital Library, "EZID" system (n2t.net/ezid/).

Documentation files

crcns_hc-10_data_description.pdf