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About hc-18

Information about the hc-18 data set.


Action potentials and local field potentials (LFPs) were recorded from the dorsal hippocampus (CA1) of five Long-Evans rats during sleep and behavior. During behavior, the rats were placed on a miniature treadmill transported by a model train. Passive travel disrupts theta spike phase precession, unless the animals actively walk on a treadmill (Cei et al., 2014). In subsequent subsessions, the treadmill was either turned off or on to selectively perturb theta phase precession or leave it intact. Perturbation of theta phase precession impaired theta sequences and subsequent sleep replay. This provided evidence that theta sequences are critical to store initial memory traces that are subsequently replayed for memory consolidation. Results from the experiments are described in:

C. Drieu, R. Todorova and M. Zugaro (2018). Nested Sequences of Hippocampal Assemblies During Behavior Support Subsequent Sleep Replay. Science 362(6415):675-679, doi: 10.1126/science.aat2952.

The data set includes 5 sessions, each consisting of three travel sessions (passive, active, passive; 2×~15 laps each) interspersed with sleep sessions (~90 min each). Hippocampal signals were recorded bilaterally using sixteen independently movable tetrodes or octrodes (64‒128 channels). Data include sorted spikes (times, clusters, featres,  and full waveforms), LFPs (at 1250 Hz), positions (coordinates of head-mounted LEDs), and experiment descriptions. They are provided in the standard, open NeuroSuite format (L. Hazan,, see Hazan et al., 2006). Data analyses described in Drieu et al. (2018) used our free (GPL-licensed) Freely Moving Animal Toolbox (FMAToolbox, M. Zugaro, and custom scripts provided in the archive.

Format of the data

The open data format is described in Hazan et al. (2006) and on our NeuroSuite website (L. Hazan, Data can be readily loaded in Matlab using our free (GPL-licensed) Freely Moving  Animal Toolbox (FMAToolbox, M. Zugaro,, which also includes extensive documentation..  Total data size is about 44 GB.

Conditions for using the data

Please contact Céline Drieu (or Michaël Zugaro) if you are planning to use this data for a publication in order to discuss potential authorship. In any case, if you publish any work using the data, please cite the publication above (Drieu et al., 2018) and the data set using the following:

C. Drieu, R. Todorova and M. Zugaro (2018). Bilateral recordings from dorsal hippocampal area CA1 from rats transported on a model train and sleeping.

The above citation uses a Digital Object Identifier (DOI) which is assigned to the data set.  The DOI was created using DataCite ( and the California Digital Library, "EZID" system (

How to download the data

The data may be downloaded from:
Using a account.  See the download link for more information about downloading.

Getting help using the data.

If you have questions about using the data, post them on the forum for using data sets.

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