About hc-28

Summary

This data set contains recordings from hippocampus regions CA1 (primarily dorsal CA1 and some intermediate CA1 recordings) and medial prefrontal cortex (PFC, prelimbic and infralimbic regions) from three male Long-Evans rats learning a continuous alternation W-track task. The data was used to determine relationships between activity in hippocampus and PFC neurons to learning, memory and decision making. The main behavior performed by the animal during the experiments was an alternate choice task in a W-shaped maze for 8 days, with interleaved behavior and rest sessions. After achieving stable performance, animals perform the same task in novel and familiar environments in alternating epochs for the final 3 days. The data was used to produce results described in the following papers:

Jadhav SP*, Rothschild G*, Roumis DR, Frank LM. (2016). Coordinated excitation and inhibition of prefrontal ensembles during awake hippocampal sharp-wave ripple events. Neuron. 90(1):113-127. PMID: 26971950. PMCID: PMC4824654. doi: 10.1016/j.neuron.2016.02.010

Tang W, Shin JD, Frank LM, Jadhav SP (2017), “Hippocampal-prefrontal reactivation during learning is stronger in awake as compared to sleep states”, Journal of Neuroscience, 37(49): 11789-11805. PMID: 29089440. PMCID: PMC5719968. doi: 10.1523/JNEUROSCI.2291-17.2017

Format of the data

The data is stored in matlab files. Details are about the data format is given in the document linked to at the bottom of this page. Total data size is about 7.8 GB.

Conditions for usage of this data in publications

These data required years of effort to collect, and it is the lab policy that anything published using these data list the person who collected the data and Dr. Jadhav as authors. Please contact Dr. Jadhav if you would like to discuss this ([email protected]).

The data set was collected by Dr. Shantanu Jadhav.

Shantanu P. Jadhav and Loren M. Frank (2020). Simultaneous extracellular recordings from hippocampal area CA1 and medial prefrontal cortex from rats performing a W-track alternation task. CRCNS.org.
http://dx.doi.org/10.6080/K02N50G9

The above citation uses a Digital Object Identifier (DOI) which is assigned to the data set.  The DOI was created using DataCite (www.datacite.org) and the California Digital Library, "EZID" system (ezid.cdlib.org).

How to download the data

Data may be downloaded from:
https://portal.nersc.gov/project/crcns/download/hc-28
A CRCNS.org account is required.

Getting help using the data

If you have questions about using the data, please post them on the forum for using data sets.

Documentation files