About ssc-7

Summary of the data

These experiments measure spikes and membrane potential in the mouse somatosensory thalamocortical system (Yu, Gutnisky et al Nat. Neurosci. 2016). Mice performed an active object localizatiobn behavior (as in O’Connor, D JNS 2010). Importantly, whisker movements and touch forces were tracked with millisecond time-scale precision (as in Pammer et al JNS 2013; Hires, Gutnisky et al ELife 2015). Spikes were recorded in VPM, L4 excitatory neurons, and L4 fast-spiking, parvalbumin-expressing interneurons. Importantly, L4 recordings were made with loos-seal pipettes to avoid sampling bias. Membrane potential is in addition recorded in L4 excitatory neurons and L4 fast-spiking neurons. Various optogenetic manipulations were performed to identify neuron types and to analyze the flow of excitation in the circuit.  The experiments and methods are described in: 

Yu, J., Gutnisky, D.A., Hires, S.A., and Svoboda, K. (2016). Layer 4 fast-spiking interneurons filter thalamocortical signals during active somatosensation. Nat Neurosci. 2016 Dec;19(12):1647-1657. doi: 10.1038/nn.4412. Epub 2016 Oct 17.

Please pay special attention to the supplemental material.

Format of the data

The data is stored in NWB format (version 1.0.6). The structure of the files are described in the document linked to at the end of this page. Total data size is about 5.8 GB (compressed).

Conditions for usage of this data in publications

If you publish any work using the data, please cite the publication above (Yu et al., 2016) also cite the data set using the following:

Jianing Yu, Diego Gutnisky, S. Andrew Hires, Karel Svoboda (2017); Data related to: Layer 4 fast-spiking interneurons filter thalamocortical signals during active somatosensation. Yu, Gutnisky, Hires, Svoboda, Nature Neurosci. 2016. CRCNS.org.
http://dx.doi.org/10.6080/K0T43R01

The above citation uses a Digital Object Identifier (DOI) which is assigned to the data set.  The DOI was created using DataCite (www.datacite.org) and the California Digital Library, "EZID" system (ezid.cdlib.org).

How to download the data

Data may be downloaded from:
https://portal.nersc.gov/project/crcns/download/ssc-7
A CRCNS.org account is required. See the download link for more instructions.

Getting help using the data

If you have questions about using the data, please post them on the forum for using data sets.

Documentation files

crcns_ssc-7_data_description.pdf