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About pvc-9

Information about the data including cells, stimuli, format of the data and how to download the data.

Summary of the data

This dataset contains patch-clamp recordings from individual pyramidal cells in layer 4 of acute slices from visual cortex area V1 in young (1-2 week old) guinea pigs. The main purpose of the experiments was to examine synaptic plasticity responses of responses evoked by electrical stimulation under normal conditions and under GABAA blockage (using bath application of bicuculline). There are three sets of data: a voltage clamp control dataset (VC, n=17), a current clamp control dataset (ICS, n=21) and a bicuculline voltage clamp dataset (VCB, n=38).

Complete recordings contain a baseline of at least 10 minutes, followed by a pairing protocol in which extracellular stimulation was paired with an intracellularly-evoked (in current clamp) burst of spikes and a post-pairing epoch of at least 10 minutes. Some datasets are incomplete or were excluded from publication due to quality control (see below). This is indicated in the accompanying documentation.

Results will be described in an upcoming PLoS One publication (*to be updated as soon as publication is complete*)

Format of the data

Data is in proprietary format (.abf files) used by Axon instruments. A utility to convert these files to Matlab form included.  Total size of the data is about 1.1 GB compressed.  Details about the data are described in document crcns_pvc-9_data_description.pdf.

How to download the data

Data may be downloaded from:
A account is required. See the download link for more instructions.

Getting help using the data

If you have questions about using the data, please post them on the forum for using data sets.

How to cite the data

See the conditions for use section in the data description document for complete instructions. In addition to citing the paper listed above, publications created through usage of the data should cite the data set in the following recommended format:

Saez, I and Friedlander, MJ (2016). Patch-clamp recordings from layer 4 pyramidal cells in guinea pig V1 acute slices showing synaptic plasticity induced by paired extracellular stimulation and spiking under both normal conditions and pharmacological GABAA blockage

The above citation uses a Digital Object Identifier (DOI) which is assigned to the data set.  The DOI was created using DataCite ( and the California Digital Library, "EZID" system (

Documentation file

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